Sickle Genetics 101

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What Is Sickle Cell Disease? - NHLBI, NIH
Sickle cell disease — also called sickle cell anemia — is a group of inherited disorders that affect hemoglobin , the major protein that carries oxygen in red blood cells. Normally, red blood cells are disc-shaped and flexible so they can move easily through the blood vessels.

Sickle Cell Disease - Causes and Risk Factors | NHLBI, NIH
Sickle cell disease is sometimes called sickle cell anemia. People have sickle cell trait if they inherit a copy of the sickle cell gene from one parent and a copy of the gene for normal hemoglobin, called hemoglobin A, from the other.

Sickle Cell Disease - Treatment | NHLBI, NIH
Treatment options for sickle cell disease include medicines that lessen symptoms, blood transfusions, blood and bone marrow transplants, and gene therapy treatments. Bone marrow transplants and gene therapies are potential cures for some people.

Sickle Cell Disease - Symptoms | NHLBI, NIH
Sickle Cell Disease Fact Sheet Learn basics about sickle cell disease, including symptoms, how to prevent health problems and treatment options.

How Sickle Cell Disease May Affect Your Health - NHLBI, NIH
Sickle cell disease can cause pain, infections, and joint problems throughout the body. It can also lead to severe anemia and complications in specific body parts.

Sickle Cell Disease - Sickle Cell Trait | NHLBI, NIH
Sickle cell trait occurs when a person has one copy of the sickle cell gene passed down from one parent, and a normal hemoglobin gene from the other parent. People who have sickle cell trait are sometimes called carriers . Sickle cell trait is different from sickle cell disease.

Sickle Cell Disease Fact Sheet - NHLBI, NIH
Sickle cell disease (SCD) is the most common inherited blood disorder in the United States. In this fact sheet, learn about the causes, signs and symptoms, diagnosis, and treatment of SCD.

Evidence-Based Management of Sickle Cell Disease: Expert Panel Report ...
The purpose of these guidelines is to help people living with sickle cell disease (SCD) receive appropriate care by providing the best science-based recommendations to guide practice decisions. The target audience is primary care providers and other clinicians, nurses, and staff who provide emergency or continuity care to individuals with SCD.

September is National Sickle Cell Awareness Month - NHLBI, NIH
Other Sickle Cell Disease Resources Understanding sickle cell disease — Learn more about sickle cell disease, including symptoms, treatments, and lifestyle tips. Cure Sickle Cell Initiative — See how NHLBI-led research is paving the way for sickle cell disease cures.

Sickle Cell Disease: Research, Programs, and Progress
Sickle cell disease (SCD) is a group of painful and life-threatening genetic disorders that affect hemoglobin, the major protein that carries oxygen in red blood cells.

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Vertex’s CRISPR treatment for sickle cell disease hits unexpected roadblock  statnews.com
Patients, advocates raise concerns over care Charleston sickle cell center  Live 5 News
Blood screen may spot potential complications in sickle cell children  Sickle Cell Disease News
Music legend who led America’s most successful girl-group while battling sickle cell  Daily Nation
Ugandan biotech unveils sickle cell cure millions can afford  Uganda Observer
Challenges for a crucial sickle cell treatment and the latest outlook for GLP-1s  statnews.com
Medicaid has a new way to pay for costly sickle cell treatment: Only if it works  NPR
Angella Ferguson, a Leader in Sickle Cell Anemia Research, Dies at 100  The New York Times
MUSC Health responds to concerns regarding sickle cell pain management practices  The Medical University of South Carolina
Sickle Cell Advocacy Day at the Statehouse  WIBC
When Music Educates: How Music Brings Life Is Transforming Sickle Cell Awareness in Schools  The National Law Review
Advancing early detection for kidney disease in sickle cell  Children's National Hospital
Spherix Global Insights Reveals Persistent High Disease Burden and Heavy Reliance on Pain Management in U.S. Sickle Cell Disease Despite Awareness of Disease-Modifying Therapies  Yahoo Finance Singapore
Blood Donations Urgently Needed to Support Sickle Cell Patients in Our Community  Los Angeles Sentinel
Sickle cell patients ask for individualized care, say MUSC treatment is oversimplified  WCIV